All-conquering Liverpool have been halted in their triumphant tracks by struggling second-division side Plymouth Argyle, who have knocked them out of the FA Cup with a stunning 1-0 fourth-round victory.

It ended any hopes of a quadruple of major trophies for Liverpool, who lead the Premier League by six points with a game in hand, finished top of the revamped first stage of the Champions League and have reached the League Cup final.

Ryan Hardie's 53rd-minute penalty on Sunday proved the winner for Plymouth, a club from the south-west of England, who are in last place in the second-tier Championship and recently fired Wayne Rooney as their manager.

"We all came here today with a dream," Hardie said, "and we have done it."

Liverpool fielded a heavily rotated line-up, resting stars like Mohamed Salah, Cody Gakpo and Virgil van Dijk, but still had established internationals like Darwin Nunez, Luis Diaz and Diogo Jota on the field in a frenetic ending as Plymouth were forced to defend doggedly.

At the end of a nerve-shredding nine minutes of stoppage time, Plymouth goalkeeper Conor Hazard produced a stunning save to tip over a header from Nunez and then kept out another header from Liverpool goalkeeper Caoimhin Kelleher after he came up for a corner.

The crucial moment was when Harvey Elliott raised his hands to stop the ball entering the penalty area and the referee awarded a handball. Hardie composed himself and slotted his spot kick the opposite direction to where Kelleher dived.

Liverpool manager Arne Slot congratulated Plymouth and acknowledged his team "hardly created anything at all."

"Probably our best part of the game was the last 10 minutes, so that tells you we kept on fighting," Slot said. "But credit to them ? good game plan and they worked incredibly hard."

Plymouth became the first club from outside the Premier League to beat a team leading the top flight since Wigan eliminated Manchester City in February 2018.

There were fabulous scenes at the final whistle as Plymouth players hugged each other on the field and fans did the same in the stands at Home Park.

Liverpool are eight-time winners of the FA Cup, most recently in 2022.

In the day's late tie, there was more misery for Spurs boss Ange Postecoglou as his side got knocked out of their second Cup competition in the space of four days, losing 2-1 at Aston Villa.

Villa had already scored through Jacob Ramsey ? after just 57 seconds ? and Morgan Rogers when Marcus Rashford entered as a Villa substitute in the 66th minute, a week after joining on loan from Manchester United.

The striker made his presence felt immediately, catching Kevin Danso with an elbow to the head that left blood pouring from the Tottenham defender. Rashford had a couple of half-chances on the break but couldn't mark his first appearance with a goal.

Mathys Tel, a deadline-day signing, pulled a goal back in stoppage time for Tottenham, who had lost to Liverpool in the League Cup semi-final in midweek.

At Blackburn, Brazilian players Joao Gomes and Matheus Cunha scored in the space of two minutes to send Wolverhampton through with a 2-0 win.