The Kansas City Chiefs have ruled out All-Pro left guard Joe Thuney for the Super Bowl because of a pectoral injury.

However, wide receiver Rashee Rice and running back Clyde Edwards-Helaire appear ready to go for the game in Las Vegas on Sunday (Monday AEDT).

Rice was a full participant in practice on Friday after he was stepped on near the end of the previous day's workout, while Edwards-Helaire also put in a full practice after dealing with an illness earlier in the week.

The only player the Chiefs listed as questionable on the final injury report was running back Jerick McKinnon, who remains on injured reserve after surgery in January for a core muscle injury.

The Chiefs have until Saturday afternoon to add him on to the active roster for the Super Bowl, though Reid described his chances of playing as "slim" earlier in the week.

The San Francisco 49ers are healthy headed into the game, with no one on the active roster listed with an injury designation.

"Guys have worked hard these two weeks," 49ers coach Kyle Shanahan said.

"The guys who have been banged up, they've done everything possible to be healthy for this game. It's our first time everyone is full and healthy. It's the right game to have it that way."

Back-up defensive tackle Kalia Davis, who is currently on injured reserve but has practised this week, was listed as questionable for San Francisco with an ankle injury. He is not expected to be activated to play.

Chiefs coach Andy Reid insisted all week he wasn't counting Thuney out, right through the end of a 66-minute workout on Friday at the practice facility of the AFC West rivals the Raiders.

But given Thuney had not practised since before he was hurt in the divisional round in Buffalo, it had become increasingly clear that Nick Allegretti would start in his place.

The long-time back-up has done this before - Allegretti also started the Super Bowl against Tampa Bay in 2021 because of injuries.

The Chiefs experienced a scare near the end of Thursday's practice when Rice was accidentally stepped on and limped off the field.

The rookie wide receiver has become one of Patrick Mahomes' go-to targets, catching 20 passes for 223 yards and a score in three play-off games, while also helping draw attention away from tight end Travis Kelce.